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Construction and Implementation of Carbon Fiber Microelectrode Arrays for Chronic and Acute In Vivo Recordings

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Laser-patterned epoxy-based 3D microelectrode arrays for extracellular recording.

Hu Peng¹, Inola Kopic¹, Shivani Ratnakar Potfode¹

¹Neuroelectronics, Munich Institute of Biomedical Engineering, Department of Electrical Engineering, TUM School of Computation, Information and Technology, Technical University of Munich, Hans-Piloty-Str. 1, 85748, Garching, Germany.

|July 16, 2024

Summary

This summary is machine-generated.

Researchers developed a fast method for creating 3D microelectrode arrays using laser patterning. These novel platforms effectively record cellular electrophysiological signals in non-planar environments.

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Area of Science:

Biomedical Engineering
Materials Science
Neuroscience

Background:

Microelectrode arrays are crucial for studying cellular electrophysiology.
There's a growing need for advanced 3D microelectrode array platforms.
Existing fabrication methods can be complex and time-consuming.

Purpose of the Study:

To present a novel, rapid fabrication process for epoxy-based 3D microelectrode array platforms.
To demonstrate the utility of laser-patterning technology in creating these 3D structures.
To evaluate the performance and recording capabilities of the fabricated 3D microelectrode arrays.

Main Methods:

Fabrication involved photopatterning 3D epoxy pillars as scaffolds.
Laser patterning was used for platinum electrode and conductor trace deposition.
Parylene-C was employed for insulation, with vertical laser ablation exposing microelectrodes.
Electrochemical impedance spectroscopy and compression tests were performed.

Main Results:

The fabrication process was demonstrated to be fast and efficient.
The resulting 3D microelectrode arrays exhibited low impedance (∼10 kΩ at 1 kHz).
The 3D structures showed mechanical stability, withstanding ∼0.6 N per pillar.
Extracellular signals, including action potentials, were successfully recorded from HL-1 cells.

Conclusions:

The developed laser-patterning technique enables rapid fabrication of epoxy-based 3D microelectrode arrays.
These arrays are suitable for recording electrophysiological signals from cells in non-planar configurations.
This technology holds promise for advancing cellular electrophysiology research in complex environments.