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Related Experiment Video

Updated: Jun 20, 2026

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

Published on: June 8, 2016

Plant-Based Shape Memory Cryogel for Hemorrhage Control.

J Deng^1,2, Z Zhao³, X Y Yeo⁴

¹School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.

Advanced Materials (Deerfield Beach, Fla.)

|July 16, 2024

Summary

This summary is machine-generated.

Biosafe pollen cryogels offer a sustainable solution for treating deep wounds. These novel hemostats are derived from natural pollen, requiring no harmful crosslinkers and demonstrating rapid blood-clotting capabilities.

Keywords:

bioinspired materials deep noncompressible wounds hemostatic materials self‐crosslinking pollen cryogel

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Last Updated: Jun 20, 2026

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Published on: October 28, 2022

Area of Science:

Biomaterials Engineering
Materials Science
Medical Device Development

Background:

Growing demand for sustainable manufacturing in healthcare.
Challenges in sourcing renewable materials and efficient fabrication for medical applications.
Need for advanced hemostatic agents for deep, noncompressible wounds.

Purpose of the Study:

To engineer biosafe pollen cryogels as effective hemostats.
To develop a sustainable and low-energy fabrication method for cryogels.
To evaluate the hemostatic performance and applicability of pollen cryogels for deep wound treatment.

Main Methods:

Fabrication of macroporous cryogels using non-allergenic plant pollen.
Characterization of cryogel properties, including shape-memory effect and structural features.
In vivo testing of hemostatic efficacy in a mouse liver penetration model.

Main Results:

Pollen cryogels were successfully synthesized using a straightforward, low-energy method.
The cryogels exhibited rapid water/blood-triggered shape-memory properties (within 2 seconds).
Effective hemostasis was demonstrated in a preclinical model, with easy removal post-usage.

Conclusions:

Self-crosslinking pollen cryogels provide a sustainable and effective hemostatic material.
The unique properties of pollen enable the creation of advanced biomaterials for medical use.
This work presents a novel framework for clinical applications in treating deep noncompressible wounds.