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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

381
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
381
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.5K
  1. Home
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  11. Blood Eosinophilia And A Higher Ethmoid Sinus/maxillary Sinus Score Ratio Predict New-onset Asthma In Patients With Chronic Rhinosinusitis With Nasal Polyps.
  1. Home
  3. Research Domains
  5. Physical Sciences
  7. Condensed Matter Physics
  9. Surface Properties Of Condensed Matter
  11. Blood Eosinophilia And A Higher Ethmoid Sinus/maxillary Sinus Score Ratio Predict New-onset Asthma In Patients With Chronic Rhinosinusitis With Nasal Polyps.

Related Experiment Video

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

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Blood eosinophilia and a higher ethmoid sinus/maxillary sinus score ratio predict new-onset asthma in patients with chronic rhinosinusitis with nasal polyps.

Kun Du1,2, Zhihui Pang1,2, Hongfei Lou1,2,3

  • 1Department of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, PR China.

Acta Oto-Laryngologica
|July 16, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
AsthmaLund-Mackay scoreallergic rhinitisblood eosinophilia

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Chronic rhinosinusitis with nasal polyps (CRSwNP) increases asthma risk. Higher sinus scores and blood eosinophil levels in CRSwNP patients independently predict new-onset asthma, highlighting key risk factors.

Area of Science:

  • Otolaryngology
  • Pulmonology
  • Immunology

Background:

  • The relationship between Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma onset remains unclear.
  • CRSwNP is a common condition affecting the upper airways.

Purpose of the Study:

  • To investigate the potential role of CRSwNP in the development of asthma.
  • To identify risk factors associated with new-onset asthma in CRSwNP patients.

Main Methods:

  • Retrospective analysis of 624 CRSwNP patients diagnosed between January 2018 and May 2021.
  • Evaluation of clinical data including nasal symptoms, Lund-Mackay scores (ethmoid/maxillary sinuses - E/M), blood eosinophil percentage, and asthma onset.
  • Statistical analysis using Kaplan-Meier curves and Cox regression models to determine asthma-free rates and risk factors.
chronic rhinosinusitis
nasal hyperreactivity
nasal polyp

Main Results:

  • Asthma prevalence was 10.90% in the CRSwNP cohort, with 3.14% developing new-onset asthma.
  • Elevated Lund-Mackay scores for ethmoid/maxillary sinuses (E/M) and higher blood eosinophil percentages were identified as independent risk factors for asthma onset.
  • Specific thresholds, E/M ratio > 2.33 or blood eosinophil percentage > 5.5%, indicated increased risk for asthma development.

Conclusions:

  • Blood eosinophilia and high E/M sinus scores are significantly associated with new-onset asthma in patients with CRSwNP.
  • These findings suggest that CRSwNP may contribute to asthma development, particularly in patients with specific biomarkers.
  • Identifying at-risk individuals through these parameters could aid in early intervention strategies.