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Updated: Jun 21, 2025
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
Retraction Note: Fas/FasL induces myocardial cell apoptosis in myocardial ischemia-reperfusion rat model
1Department of Cardiology, Tangshan Gongren Hospital, Tangshan, Hebei, China.
Abstract:
The article "Fas/FasL induces myocardial cell apoptosis in myocardial ischemia-reperfusion rat model", by X.-M. Liu, Z.-M. Yang, X.-K. Liu, published in Eur Rev Med Pharmacol Sci 2017; 21 (12): 2913-2918- PMID: 28682425 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/29CE1A59A8180E414855FA3871BCAC), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The authors were informed about the journal's investigation but remained unresponsive and have not provided the manuscript's raw data. The journal's investigation revealed a figure overlap between panels 10 U/mL and 100 U/mL in Figure 1. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/12953.
Insights
This study on myocardial ischemia-reperfusion in rats has been retracted due to concerns about data validity and figure manipulation. The journal retracted the article after the authors failed to respond to an investigation.
Area of Science:
- Cardiology
- Cell Biology
- Pharmacology
Context:
- Myocardial ischemia-reperfusion injury is a significant clinical concern.
- The Fas/FasL pathway has been implicated in cardiac cell apoptosis.
- Previous research aimed to explore the role of Fas/FasL in myocardial damage.
Purpose:
- To investigate the role of Fas/FasL in inducing myocardial cell apoptosis in a rat model of myocardial ischemia-reperfusion.
- To assess the therapeutic potential of targeting the Fas/FasL pathway.
Summary:
- The article investigated Fas/FasL-mediated apoptosis in myocardial ischemia-reperfusion.
- Concerns regarding figure manipulation and data integrity were raised on PubPeer.
- An investigation revealed figure overlap, leading to mistrust of the presented results.
- The authors were unresponsive to the journal's inquiry and did not provide raw data.
- Consequently, the article has been retracted by the Editor in Chief.
Impact:
- The retraction highlights the importance of rigorous data verification in scientific publishing.
- It underscores the need for transparency and author responsiveness during scientific investigations.
- This retraction impacts the body of literature concerning Fas/FasL in myocardial injury, necessitating further validated research.
