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Updated: Jun 21, 2025

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium
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Published on: December 17, 2018

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Unveiling the Hub Genes Involved in Cadmium-Induced Hepatotoxicity

Bing Yang1, Zhongyuan Wang1, Shujuan Wang1

  • 1College of Animal Science, Anhui Science and Technology University, Fengyang, 233100, China.

Biological Trace Element Research
|July 16, 2024
PubMed

Insights

This study identifies key genes, including CYP2E1 and HSP90B1, involved in cadmium-induced liver damage. These findings enhance understanding of cadmium

Area of Science:

  • Toxicology
  • Molecular Biology
  • Genomics

Background:

  • Cadmium (Cd) is a toxic heavy metal causing significant liver damage.
  • The precise genetic mechanisms of Cd-induced hepatotoxicity remain unclear.

Purpose of the Study:

  • To identify key genes associated with cadmium chloride (CdCl2)-induced liver damage in rat hepatocytes.
  • To elucidate the molecular pathways involved in Cd-induced hepatotoxicity.

Main Methods:

  • Analysis of the GSE19662 dataset from the Gene Expression Omnibus (GEO).
  • Identification of differentially expressed genes (DEGs) in rat hepatocytes treated with CdCl2.
  • Gene Ontology (GO) and pathway analysis.

Main Results:

  • 851 DEGs were identified, with 438 upregulated and 413 downregulated.
  • DEGs were primarily linked to inflammatory responses and xenobiotic metabolism.
  • Hub genes such as CYP2E1, HSP90B1, and MAPK8 were identified, associated with pathways like chemical carcinogenesis and inflammatory mediator regulation.

Conclusions:

  • This study pinpoints critical genes and pathways involved in Cd-induced liver damage.
  • The findings offer insights into the molecular mechanisms of cadmium hepatotoxicity.
Keywords:
CadmiumGeneHepatotoxicitySignaling pathway

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