Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The pancreas and alcohol].

M V Singer

    Schweizerische Medizinische Wochenschrift
    |July 20, 1985
    PubMed
    Summary

    Ethanol affects pancreatic exocrine secretion. Acute ethanol inhibits secretion, while chronic alcoholism alters enzyme and bicarbonate output, potentially leading to pancreatitis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells.

    Biochemical and biophysical research communications·2016
    Same author

    [New international classification of chronic pancreatitis (2007) M-ANNHEIM].

    Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2011
    Same author

    Interfering with interferon-γ signalling in intestinal epithelial cells: selective inhibition of apoptosis-maintained secretion of anti-inflammatory interleukin-18 binding protein.

    Clinical and experimental immunology·2010
    Same author

    [Toluidin blue in gastrointestinal endoscopy].

    Zeitschrift fur Gastroenterologie·2010
    Same author

    How general practitioners manage patients with irritable bowel syndrome. Data from a German urban area.

    Romanian journal of internal medicine = Revue roumaine de medecine interne·2009
    Same author

    [The problems of compliance and adherence, using the example of chronic inflammatory bowel disease].

    Deutsche medizinische Wochenschrift (1946)·2009

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Pancreatology

    Background:

    • Ethanol's impact on pancreatic exocrine function is complex and varies with administration route and duration.
    • Understanding these effects is crucial for diagnosing and managing alcohol-related pancreatic diseases.

    Purpose of the Study:

    • To review the effects of acute and chronic ethanol administration on pancreatic exocrine secretion in humans and animals.
    • To explore the mechanisms underlying ethanol's actions on the pancreas, including hormonal and neural pathways.

    Main Methods:

    • Review of existing literature on ethanol's effects on pancreatic secretion.
    • Analysis of experimental data considering variables like administration route (intravenous, oral, intraduodenal) and duration (acute, chronic).

    Main Results:

    • Acute intravenous ethanol inhibits basal and stimulated pancreatic secretion of bicarbonate and protein.
    • Oral or intraduodenal ethanol moderately stimulates pancreatic bicarbonate and enzyme secretion.
    • Chronic alcoholism leads to increased basal enzyme secretion and decreased basal bicarbonate output, potentially promoting protein precipitates and pancreatitis.

    Conclusions:

    • Ethanol's pancreatic effects may involve inhibitory cholinergic mechanisms and gastrointestinal hormone release (e.g., gastrin).
    • Chronic alcohol-induced secretory changes, including decreased pancreatic stone protein, may contribute to the pathogenesis of chronic pancreatitis.

    Related Experiment Videos