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Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

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Emerging platelet-based drug delivery systems.

Mengkun Fang1, Rui Liu1, Yile Fang1

  • 1Department of haematology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210002, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|July 16, 2024
PubMed
Summary
This summary is machine-generated.

Platelets offer a promising solution for drug delivery, overcoming limitations of engineered nanoparticles. This review explores various platelet-based systems for enhanced therapeutic targeting and reduced side effects.

Keywords:
Drug delivery systemGenetic engineeringMembranePlateletTumor

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Engineered nanoparticles face challenges in targeted drug delivery, including toxicity and immunogenicity.
  • Living cells, particularly platelets, possess innate targeting and minimal adverse effects, making them attractive drug carriers.
  • Platelets are involved in hemostasis, inflammation, and tumor progression, highlighting their therapeutic potential.

Purpose of the Study:

  • To review current advancements in platelet-based drug delivery systems.
  • To highlight various strategies for utilizing platelets as drug carriers.
  • To discuss the potential applications of these systems in different therapeutic areas.

Main Methods:

  • Review of existing literature on platelet-based drug delivery.
  • Categorization of methods including platelet membrane engineering, coating, and cytoplasmic loading.
  • Inclusion of genetic engineering and synthetic/artificial platelet approaches.

Main Results:

  • Platelet-based systems demonstrate improved targeting compared to traditional nanoparticles.
  • Various methods offer distinct advantages for drug encapsulation and release.
  • Engineered platelets show potential for diverse applications in disease treatment.

Conclusions:

  • Platelet-based drug delivery systems present a viable alternative to overcome current limitations.
  • Further research into platelet engineering and synthetic platelets can unlock new therapeutic avenues.
  • These systems hold significant promise for targeted and effective drug delivery across various medical fields.