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Paediatric Anatomical Models in Radiotherapy Applications.

V Apte1, A Ghose2, C A Linares3

  • 1Medical School, University College London, London WC1E 6BT, UK.

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|July 16, 2024
PubMed
Summary
This summary is machine-generated.

Age-specific computational phantoms, including International Commission on Radiological Protection (ICRP) and 4D extended cardiac torso (XCAT), show potential for modeling pediatric radiotherapy. While RT-PAL is best for patients undergoing treatment, ICRP and XCAT can model healthy pediatric populations.

Keywords:
Age-specificOrgan volumePaediatric cancerPhantomsRadiotherapy

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Area of Science:

  • Medical Physics
  • Radiotherapy
  • Computational Modeling

Background:

  • Anatomical models are crucial in radiotherapy for understanding radiation dose and side effect risks.
  • Age-specific computational phantoms are essential for accurate pediatric radiotherapy planning.

Purpose of the Study:

  • To evaluate the adequacy of computational phantoms (ICRP, XCAT, RT-PAL) for modeling pediatric populations.
  • To compare organ volume data across phantoms and literature for different age groups.

Main Methods:

  • Organ volume data for 19 organs were collected for ICRP, XCAT, RT-PAL phantoms and literature data.
  • Percentage differences (P.D) were calculated relative to the ICRP phantom for each age category (1, 5, 10, 15) and organ.
  • Statistical analysis included linear regression to assess the correlation between organ volume and age.

Main Results:

  • Literature data showed the smallest P.D (-17.4%) to ICRP, followed by XCAT (26.6%), and RT-PAL (88.1%).
  • The rectum had the largest average P.D (1,049.2%), while the large bowel had the smallest (2.0%).
  • P.D decreased from 122.6% at age 1 to 43.5% at age 15; ICRP showed the strongest correlation (R²=0.943) between organ volume and age.

Conclusions:

  • The evaluated phantoms are sufficiently similar to ICRP for potential use in pediatric population modeling.
  • ICRP and XCAT are suitable for modeling healthy pediatric populations.
  • RT-PAL is recommended for modeling pediatric populations undergoing or having undergone radiotherapy.