Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of organic fruit juices on physicochemical, microbiological, and antioxidative aspects of fermented whey beverages from organic goat and cow milk, produced at laboratory and industrial scales.

Journal of dairy science·2024
Same author

Pneumothorax as a Poor Prognostic Indicator in COVID-19 in Turkey: A Propensity Score Matching Analysis.

Nigerian journal of clinical practice·2024
Same author

Sedation with Propofol and Propofol-Ketamine (Ketofol) in Flexible Bronchoscopy: A Randomized, Double-Blind, Prospective Study.

Nigerian journal of clinical practice·2023
Same author

Electrochemical biosensor for aerobic acetate detection.

Talanta·2023
Same author

Follicular fluid redox balance and DNA damage according to PCOS phenotype.

European review for medical and pharmacological sciences·2023
Same author

Automated detection, delineation and quantification of whole-body bone metastasis using FDG-PET/CT images.

Physical and engineering sciences in medicine·2023
Same journal

Concordance Between Planned and Delivered treatment for Head and Neck Cancer Patients Treated With Curative Intent: A Real-World Comparison of Under 70-year-olds With 70-year-olds and Over.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

A Novel Technique for Pain Management to Deliver a Course of Palliative Radiotherapy.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Broad-Spectrum Antibiotics are Associated with worse Survival After Radical Treatment for Glioblastoma Multiforme: A Multicentre Study.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Exploring the Need for Plan Adaptation in Robustly Optimised Head and Neck Intensity Modulated Proton Therapy: A Dosimetric Perspective From Initial Institutional Experience.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Lifting the Lid on Best Practice in a Case of Oligometastatic Breast Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Standardisation of Imaging Surveillance for Patients With Metastatic Melanoma Stopping Immune Checkpoint Inhibitors.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.3K

Assessing a Suitable Radiotherapy Utilisation Benchmark for Older Patients With Head and Neck Cancer.

P Mackenzie1, C Vajdic2, G Delaney3

  • 1FRANZCR, Royal Brisbane and Women's Hospital, University of QLD, Collaboration for Cancer Outcomes Research and Evaluation (CCORE), The University of New South Wales, Sydney, Australia.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|July 16, 2024
PubMed
Summary
This summary is machine-generated.

Radiotherapy utilization for head and neck cancer patients aged 80+ is lower than optimal, despite similar treatment completion and toxicity rates compared to younger patients. This study highlights disparities in care for older adults.

Keywords:
Geriatric oncologyhead and neck cancerradiotherapy utilisation

More Related Videos

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.3K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.2K

Related Experiment Videos

Last Updated: Jun 21, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.3K
Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.3K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.2K

Area of Science:

  • Oncology
  • Radiation Oncology
  • Geriatric Medicine

Background:

  • Head and neck cancer disproportionately affects older adults, a population often facing treatment complexities.
  • Radiotherapy utilization (RTU) in this demographic requires careful evaluation to ensure optimal care delivery.
  • Understanding age- and comorbidity-adjusted RTU is crucial for equitable cancer treatment.

Purpose of the Study:

  • To determine the actual radiotherapy utilization (RTU) in head and neck cancer patients, stratified by age.
  • To develop an optimal RTU model adjusted for age and comorbidities.
  • To assess treatment tolerance and toxicity in elderly head and neck cancer patients.

Main Methods:

  • Retrospective cohort study using New South Wales Cancer Registry and radiotherapy data (2008-2015).
  • Calculated actual RTU (proportion receiving radiotherapy within one year of diagnosis) by age group.
  • Developed age- and comorbidity-adjusted optimal RTU model; assessed radiotherapy dose, completion rates, and emergency department presentations for toxicity.

Main Results:

  • Of 5966 head and neck cancer patients, 13.6% were aged 80+.
  • Actual RTU was lower than optimal RTU across all age groups.
  • For patients aged 80+, optimal RTU was 52% (actual 40%), with 92% completion of curative 70 Gray (Gy) radiotherapy and similar emergency department presentation rates to younger groups.

Conclusions:

  • Actual radiotherapy utilization is suboptimal for head and neck cancer patients aged 80+ and across all age groups.
  • Fewer elderly patients received curative intent radiotherapy despite comparable treatment completion and acute toxicity.
  • This indicates potential underutilization of radiotherapy in older head and neck cancer patients.