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Area of Science:

  • Oncology
  • Neurology
  • Gerontology

Background:

  • Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of taxane-based chemotherapy in breast cancer patients.
  • Persistent CIPN can lead to gait, balance, and strength impairments, increasing the risk of falls and subsequent injury.
  • Understanding baseline fall risk factors is crucial for developing effective prevention strategies in this vulnerable population.

Purpose of the Study:

  • To determine the baseline fall risk among women with persistent CIPN who received taxane-based chemotherapy.
  • To identify significant predictors of future falls in this patient group.

Main Methods:

  • A prospective analysis of 62 participants with persistent CIPN from a randomized clinical trial was conducted.
  • Baseline demographic, medical, nerve conduction, gait, balance, and muscle strength data were collected.
  • Generalized linear modeling with Lasso was used to identify significant risk factors for future falls.

Main Results:

  • Near falls within the last month (OR=2.46) and reduced right ankle plantar flexion torque (OR=1.05) were significantly associated with future falls.
  • Demographic data, nerve conduction, gait, balance, and overall muscle strength did not significantly predict fall risk.
  • No significant differences in baseline characteristics were observed between the intervention and control groups.

Conclusions:

  • Near falls and ankle strength are critical, yet often overlooked, factors in assessing fall risk in breast cancer survivors with CIPN.
  • Oncology clinicians, particularly nurses, should routinely inquire about near falls and consider referrals for physical therapy to address lower extremity weakness.
  • Further research is needed to develop and evaluate evidence-based interventions to mitigate fall risk and improve functional outcomes for patients with CIPN.