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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

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Long-Acting Injectable Antipsychotics in the Geriatric Population: A longitudinal Study.

Nafiz Mosharraf¹, Tanya Peguero Estevez¹, Lisa J Cohen¹

¹Department of Psychiatry (NM, TPE, LC), Mount Sinai Behavioral Health Center, New York City, NY, United States of America.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry

|July 16, 2024

Summary

This summary is machine-generated.

Older adults on long-acting injectable antipsychotics (LAI-AP) experienced fewer hospitalizations and better treatment engagement compared to oral antipsychotics (PO-AP). Female sex was linked to LAI-AP discontinuation.

Keywords:

Antipsychotics Gender difference Long-Acting Injectables Pharmacology

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Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

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Published on: September 30, 2020

Area of Science:

Geriatric Psychiatry
Pharmacotherapy
Treatment Outcomes

Background:

Limited research exists on the efficacy and tolerability of long-acting injectable antipsychotics (LAI-AP) specifically in geriatric populations.
Understanding treatment adherence and outcomes in older adults with psychotic or mood disorders is crucial for optimizing care.

Purpose of the Study:

To compare demographic, clinical characteristics, and treatment outcomes between older adults receiving LAI-AP and oral antipsychotics (PO-AP).
To identify factors associated with the discontinuation of LAI-AP in this patient group.

Main Methods:

Retrospective cohort study of geriatric patients (≥60 years) with psychotic or mood disorders treated for at least 3 months.
Utilized electronic medical records to collect data on demographics, diagnoses, medication types, side effects, comorbidities, and secondary medications.
Outcome variables included missed appointments, psychiatric and medical hospitalizations, and emergency room visits; LAI-AP patients were analyzed for discontinuation.

Main Results:

The LAI-AP group had a higher proportion of primary psychotic disorders (87.8% vs. 64.3% for PO-AP).
PO-AP patients showed higher rates of missed appointments (18% vs. 13% for LAI-AP) and psychiatric admissions (0.019/month vs. 0.006/month for LAI-AP).
Female sex was identified as a risk factor for LAI-AP discontinuation (86.7% of discontinuation group vs. 55.2% of continuation group).

Conclusions:

LAI-AP demonstrated reduced hospitalizations and improved treatment engagement in older adults compared to PO-AP, with comparable tolerability.
Preliminary findings suggest that gender may influence LAI-AP discontinuation rates.
This study contributes valuable data to the understanding of LAI-AP use in geriatric psychiatric care.