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Updated: Jun 21, 2025

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

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Published on: March 23, 2022

Tissue microenvironment induces tissue specificity of ILC2.

Minjing Qin¹, Yuanyuan Fang¹, Qitong Zheng¹

¹School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, China.

Cell Death Discovery

|July 16, 2024

Summary

Type 2 innate lymphoid cells (ILC2s) are diverse and tissue-specific immune cells. They adapt to their microenvironment and distant tissue signals, influencing immunity and potentially transdifferentiating.

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Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

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Published on: September 20, 2019

Area of Science:

Immunology
Cell Biology

Background:

Type 2 innate lymphoid cells (ILC2s) are key players in immunity and allergic responses.
ILC2s exhibit significant diversity and tissue-specific characteristics.
The tissue microenvironment and inter-tissue crosstalk influence ILC2 function.

Purpose of the Study:

To review the tissue-specific effects of the microenvironment on ILC2s.
To highlight the role of ILC2s in inter-tissue communication.
To discuss ILC2 plasticity, including transdifferentiation.

Main Methods:

Literature review of ILC2 research.
Analysis of studies on tissue microenvironment and ILC2 function.
Examination of ILC2 interactions and plasticity.

Main Results:

ILC2s display adaptive changes regulated by tissue microenvironments and distant tissues.
Inter-tissue crosstalk significantly impacts ILC2 migration and activation.
ILC2s can transdifferentiate into other innate lymphoid cell types (ILC1, ILC3) under altered conditions.

Conclusions:

ILC2s are dynamic cells that adapt to their local and systemic environments.
Understanding ILC2 tissue specificity and plasticity is crucial for immunity and disease.
Further research into ILC2 transdifferentiation mechanisms is warranted.