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Updated: Jun 21, 2025
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High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence
Published on: February 23, 2021
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Bacterial persisters: molecular mechanisms and therapeutic development
Hongxia Niu1, Jiaying Gu1, Ying Zhang2,3
1School of Basic Medical Science and Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
Signal Transduction and Targeted Therapy
|July 16, 2024
Summary
Bacterial persisters are drug-susceptible cells surviving antibiotic stress. Understanding persister formation mechanisms is crucial for developing new treatments against persistent infections.
Area of Science:
- Microbiology
- Molecular Biology
- Infectious Diseases
Background:
- Persisters are dormant, non-growing bacteria surviving antibiotic stress.
- These cells contribute to chronic infections, treatment relapse, and drug resistance.
- Understanding persisters is vital for overcoming treatment challenges.
Purpose of the Study:
- To comprehensively review bacterial persister characteristics and formation mechanisms.
- To explore the relationship between persisters, antibiotic tolerance, and resistance.
- To consolidate current knowledge on anti-persister compounds and treatment strategies.
Main Methods:
- Literature review and synthesis of existing research on bacterial persisters.
- Analysis of historical data and current findings on persister biology.
- Consolidation of information on anti-persister strategies.
Main Results:
- Persisters are genetically susceptible but phenotypically tolerant to antibiotics.
- Complex interplay of bacterial biological processes influences persister formation.
- Diverse anti-persister compounds and treatment approaches are being investigated.
Conclusions:
- Further research into persister mechanisms is needed for effective treatment strategies.
- Targeting persisters offers a promising avenue for combating persistent infections.
- This review provides a theoretical foundation for future persister research.
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