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Related Experiment Videos

Vasoactive intestinal polypeptide: measurement, distribution and putative neurotransmitter function.

J Fahrenkrug

    Digestion
    |January 1, 1979
    PubMed
    Summary
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    Vasoactive intestinal polypeptide (VIP) is a peptide found in neurons throughout the body, acting as a potential neurotransmitter. Research suggests VIP mediates functions in the digestive and pancreatic systems via specific nerve fibers.

    Area of Science:

    • Neuroscience
    • Gastroenterology
    • Endocrinology

    Background:

    • Vasoactive intestinal polypeptide (VIP) is an octacosapeptide initially identified as a gut hormone.
    • Recent studies indicate VIP is widely distributed in neurons across the central and peripheral nervous systems.
    • VIP is found in synaptic vesicles within nerve terminals.

    Purpose of the Study:

    • To investigate the distribution and potential role of Vasoactive intestinal polypeptide (VIP) in neuronal signaling.
    • To evaluate VIP's criteria for functioning as a neurotransmitter.
    • To explore VIP's involvement in gastrointestinal and pancreatic functions.

    Main Methods:

    • Radioimmunochemical analysis to detect VIP.
    • Immunohistochemical studies to determine VIP localization in tissues.

    Related Experiment Videos

  • Assessment of VIP distribution in the central nervous system, digestive tract, genitourinary tract, and adrenal glands.

    • Main Results:

    • VIP is localized in neurons throughout various systems, including the brain (cerebral arteries), digestive, genitourinary, and adrenal glands.
    • VIP is present in synaptic vesicles, supporting its role as a neurotransmitter.
    • Evidence suggests VIP is a mediator for non-cholinergic, non-adrenergic nerve-controlled functions.

    Conclusions:

    • Vasoactive intestinal polypeptide (VIP) exhibits characteristics of a neurotransmitter in both central and peripheral nerves.
    • VIP is likely the primary mediator for gastrointestinal and pancreatic functions regulated by specific nerve pathways.