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Updated: Jun 21, 2025
Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
Published on: April 18, 2025
Cardiac response to hypertension treatment: an advanced echocardiographic evaluation
Parinaz Sedighi1,2, Amin Doosti-Irani3, Shahram Homayounfar4
1Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
Insights
Antihypertensive therapy significantly improves cardiac function and left ventricular systolic function in hypertensive patients. Early diagnosis and treatment of hypertension can reverse maladaptive cardiac remodeling, highlighting the importance of monitoring Global Longitudinal Strain.
Area of Science:
- Cardiology
- Hypertension Research
- Cardiovascular Disease
Background:
- Hypertension is a leading reversible cause of cardiovascular disease, affecting over a billion people globally.
- Sustained high blood pressure leads to adverse cardiac remodeling and dysfunction.
- This study investigates the impact of hypertension treatment on cardiac function.
Purpose of the Study:
- To evaluate the effects of antihypertensive therapy on cardiac function.
- To assess changes in systolic and diastolic parameters before and after treatment.
- To determine the reversibility of cardiac remodeling in hypertension.
Main Methods:
- A cohort of 100 hypertension patients was studied.
- Clinical and echocardiographic evaluations were performed at baseline and after 3-6 months of antihypertensive therapy.
- Global Longitudinal Strain (GLS) was a key parameter for assessing left ventricular systolic function.
Main Results:
- Antihypertensive therapy significantly reduced systolic (163.05 to 129.95 mmHg) and diastolic (95.40 to 82.35 mmHg) blood pressure (P < 0.001).
- Global Longitudinal Strain improved from -15.54% to -16.95% (P = 0.025), indicating enhanced left ventricular systolic function.
- Significant improvements were observed in parameters of systolic and diastolic function post-treatment.
Conclusions:
- Antihypertensive therapy leads to significant improvements in cardiac systolic and diastolic function within 3-6 months.
- The study demonstrates that maladaptive cardiac remodeling due to hypertension is reversible with timely diagnosis and treatment.
- Global Longitudinal Strain and diastolic dysfunction parameters are valuable for monitoring early cardiac injury in patients undergoing antihypertensive therapy.
Background:
Hypertension is the most common reversible cause of cardiovascular disease worldwide and more than one billion individuals suffer from the disease. Constant heart exposure to increased afterload progresses to maladaptive remodeling, leading to cardiac dysfunction. In this study, we aimed to evaluate cardiac function in response to hypertension treatment.
Methods:
One hundred patients diagnosed with hypertension were evaluated two times, with 3 to 6 months intervals, before and after antihypertensive therapy. Patients underwent clinical and echocardiographic evaluation in both visits and the interest effect of antihypertensive therapy on cardiac function was studied.
Results:
58 men and 42 women with a mean age of 60.81 ± 11.8 years were studied. Mean systolic and diastolic pressure in the first visit was 163.05 ± 20.6 and 95.40 ± 10.4, respectively. On the second visit, mean systolic and diastolic pressure was 129.95 ± 10.4 and 82.35 ± 7.2 respectively (P value for both < 0.001). The mean value of Global Longitudinal Strain as the main parameter for evaluating left ventricular systolic function was -15.54% on the first visit and changed to -16.95% on the second visit (P value 0.025).
Conclusions:
According to the results of this study, changes in parameters, indicator of systolic and diastolic function, after 3-6 months of antihypertensive therapy are significant. The most important point is that maladaptive remodeling of the heart is reversible if hypertension is diagnosed timely. To follow-up patients under antihypertensive therapy, GLS and parameters indicator of diastolic dysfunction, have the best diagnostic value in terms of detecting early stages of cardiac injury.
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