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Updated: Jun 21, 2025
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Interstitial lung diseases (ILD) in common variable immunodeficiency (CVID) patients: a study from Iran
Ghamartaj Khanbabaee1, Fatemeh Khazaii2, Zahra Chavoshzadeh3
1Department of Pediatric Pulmonology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Interstitial lung disease (ILD) affects 16.6% of common variable immunodeficiency (CVID) patients, often presenting with higher platelet counts and symptoms like pneumonia and diarrhea. Understanding ILD pathogenesis is key to managing non-infectious pulmonary complications in CVID.
Area of Science:
- Pulmonology
- Immunology
- Radiology
Background:
- Interstitial lung disease (ILD) is a frequent complication in common variable immunodeficiency (CVID).
- ILD diagnosis in CVID patients often relies on imaging due to limited histopathology availability.
- ILD in CVID can be associated with bronchiectasis and autoimmunity.
Purpose of the Study:
- To investigate the prevalence and characteristics of ILD in CVID patients.
- To compare demographic, clinical, laboratory, and radiological findings between CVID patients with and without ILD.
Main Methods:
- Retrospective cross-sectional study of 60 CVID patients (2013-2022).
- ILD diagnosis based on transbronchial lung biopsy or clinical/radiological evidence.
- Comparison of CVID patients with and without ILD.
Main Results:
- 16.6% of CVID patients had ILD.
- Patients with ILD showed significantly higher platelet levels, pneumonia, and diarrhea.
- Hyperinflation was more frequent in CVID patients without ILD.
Conclusions:
- ILD is a significant non-infectious pulmonary complication in CVID.
- Further research into ILD pathogenesis can improve understanding and management of CVID.
- Identifying ILD features aids in better patient care for CVID.
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