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Related Experiment Video

Updated: Jun 21, 2025

Real-Time fMRI Brain Mapping in Animals

Real-Time fMRI Brain Mapping in Animals

Published on: September 24, 2020

Common functional mechanisms underlying dynamic brain network changes across five general anesthetics: A rat fMRI

Sifan Chen^1,2,3, Bo Li^1,2,4, Ying Hu⁴

¹Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

CNS Neuroscience & Therapeutics

|July 16, 2024

Summary

General anesthetics alter brain networks by disrupting subcortical connectivity, leading to unconsciousness. This study reveals distinct network changes across different anesthetic agents in rats, offering insights into anesthetic mechanisms.

Keywords:

concordance dynamic graph theory fMRI functional connectivity general anesthesia rat stability

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Published on: January 13, 2018

Area of Science:

Neuroscience
Anesthesiology
Systems Biology

Background:

General anesthesia aims to induce reversible unconsciousness, but the underlying brain mechanisms remain elusive.
Understanding these mechanisms is crucial for safe and effective anesthetic practice.

Purpose of the Study:

To investigate how five common general anesthetics affect functional brain networks in rats.
To explore static, dynamic, topological, and organizational changes in brain networks during anesthesia.

Main Methods:

Male Sprague-Dawley rats were administered propofol, isoflurane, ketamine, dexmedetomidine, or a combination.
Resting-state functional magnetic resonance imaging (fMRI) was used to compare brain networks in awake versus anesthetized states.

Main Results:

Anesthetics induced unique patterns of functional connectivity disruption, primarily impacting cortico-subcortical networks.
Subcortical regions showed reduced information transmission, connectivity, and stability.
Cortico-cortical networks maintained functional connectivity and topology but exhibited reduced dynamic fluctuations.

Conclusions:

Different anesthetics induce distinct functional brain network reorganizations.
These findings contribute to understanding the drug-invariant mechanisms of anesthetic-induced unconsciousness.