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Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Rous Sarcoma Virus (RSV) and Cancer01:03

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RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jun 27, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Thyroblastoma in a rhesus macaque (Macaca mulatta): A case report.

J Greenberg1, D J Wiener1, S J Buchl2

  • 1Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, USA.

Journal of Medical Primatology
|July 16, 2024
PubMed
Summary

This study details a rare thyroblastoma in a young rhesus macaque. Researchers examined the tumor

Keywords:
Macaca mulattaThyroblastomaembryonal neoplasmthyroidthyroid transcription factor 1

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Area of Science:

  • Veterinary Pathology
  • Comparative Oncology

Background:

  • Thyroblastomas are rare thyroid neoplasms.
  • Tumors in non-human primates offer insights into comparative pathology.

Observation:

  • A 2-month-old rhesus macaque presented with a right thyroid lobe mass.
  • Gross examination revealed a distinct tumor.
  • Histopathological and immunohistochemical analyses were performed.

Findings:

  • The tumor was classified as a thyroblastoma.
  • Specific histopathological features were documented.
  • Immunohistochemistry aided in tumor characterization.

Implications:

  • This case expands the understanding of thyroblastomas in non-human primates.
  • Provides valuable data for comparative studies of thyroid neoplasms.
  • Contributes to the pathology database for rhesus macaques.