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Upper gastrointestinal bleeding following renal transplantation.
Urology
|October 1, 1985
Summary
Upper gastrointestinal bleeding is a serious risk after renal transplantation. This study found a 6% incidence and 8.3% mortality, emphasizing proactive management and identifying hypercalcemia as a potential factor.
Area of Science:
- Nephrology
- Transplantation Surgery
- Gastroenterology
Background:
- Upper gastrointestinal bleeding (UGIB) is a known complication following renal transplantation.
- This complication carries a significant risk of mortality and can impact allograft survival.
Purpose of the Study:
- To determine the incidence and mortality of UGIB in renal transplant recipients.
- To identify factors associated with UGIB and evaluate management strategies.
- To explore the role of hypercalcemia in post-transplant UGIB.
Main Methods:
- Retrospective review of 200 consecutive renal transplants in 194 patients.
- Analysis of patient data for UGIB incidence, mortality, and allograft survival.
- Investigation of potential contributing factors, including hypercalcemia.
Main Results:
- An incidence of 6% for UGIB was observed.
- The mortality rate associated with UGIB was 8.3%.
- Allograft survival in patients experiencing UGIB was 58%.
Conclusions:
- Careful preoperative evaluation, vigilant monitoring for early bleeding signs, and prompt intervention are crucial for managing UGIB in renal transplant patients.
- Hypercalcemia is associated with post-transplant UGIB, and parathyroidectomy may lead to cessation of bleeding.