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Updated: Jun 4, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Trace elements in pancreatic cancer.

Yao Yanjun¹, Zhuang Jing¹, Song Yifei¹

¹Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China.

Cancer Medicine

|July 17, 2024

Summary

Trace elements like selenium, copper, arsenic, and manganese impact pancreatic cancer (PCA) risk and progression. They offer potential for PCA prevention, diagnosis, and treatment by inhibiting tumor growth and spread.

Keywords:

arsenic copper manganese pancreatic cancer selenium trace elements

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Area of Science:

Oncology
Nutritional Biochemistry
Trace Element Research

Background:

Pancreatic cancer (PCA) is a highly aggressive malignancy with poor prognosis.
Late-stage diagnosis is a primary driver of high PCA mortality rates.
Trace elements are essential nutrients linked to various diseases, including PCA.

Purpose of the Study:

To review current research on selenium, copper, arsenic, and manganese in pancreatic cancer.
To elucidate the role of these trace elements in PCA.
To provide insights for PCA prevention, diagnosis, and treatment.

Main Methods:

Systematic review of recent scientific literature.
Focus on the roles of specific trace elements (selenium, copper, arsenic, manganese).
Analysis of their implications in pancreatic cancer.

Main Results:

These trace elements are significantly involved in PCA risk and pathogenesis.
They demonstrate potential in PCA diagnosis and therapeutic strategies.
Mechanisms include promoting ferroptosis, inducing apoptosis, inhibiting metastasis, and controlling proliferation.

Conclusions:

Selenium, copper, arsenic, and manganese play crucial roles in pancreatic cancer.
These elements exhibit inhibitory effects on PCA.
Understanding their mechanisms can guide future PCA management.