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Association between METS-IR and heart failure: a cross-sectional study.
Xiaozhou Su1, Chunli Zhao1, Xianwei Zhang1
1Department of Cardiology, Minzu Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Frontiers in Endocrinology
|July 17, 2024
Summary
The metabolic score for insulin resistance (METS-IR) shows a J-shaped link with heart failure (HF) risk in US adults. Higher METS-IR may predict increased heart failure risk, warranting further investigation.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Public Health
Background:
- Insulin resistance is linked to heart failure (HF) development.
- The metabolic score for insulin resistance (METS-IR) is a new measure for insulin resistance.
- The association between METS-IR and HF risk is not well understood.
Purpose of the Study:
- To investigate the relationship between METS-IR and the risk of heart failure (HF).
- To explore the nonlinear association and identify potential inflection points.
Main Methods:
- Cross-sectional study using NHANES data (2007-2018).
- Multivariable logistic regression and smoothing curve fitting were employed.
- Subgroup and ROC curve analyses were conducted for robustness.
Main Results:
- A significant positive association was found between METS-IR and HF risk (OR: 2.44).
- A J-shaped, nonlinear relationship was observed, with an inflection point at METS-IR of 40.966.
- No significant interactions were found in subgroup analyses.
Conclusions:
- A J-shaped association exists between METS-IR and HF in US adults.
- METS-IR shows potential as a novel index for predicting HF risk.
- Further longitudinal studies are needed to confirm causality and validate findings.
