Dysfunctional mitochondria elicit bioenergetic decline in the aged heart
Pasquale Mone1,2, Esther Densu Agyapong1,3, Giampaolo Morciano3,4
1Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
The Journal of Cardiovascular Aging
|July 17, 2024
Summary
Mitochondria are crucial to cardiac aging, influencing heart function decline and disease susceptibility. This review details their role in the aging heart.
Area of Science:
- Cardiology
- Gerontology
- Mitochondrial Biology
Background:
- Aging is a biological process involving tissue functional decline and increased disease risk.
- The aging heart exhibits morphological and biochemical changes, leading to reduced cardiac function.
- Mitochondria are central to aging, interacting with molecular pathways and aging factors.
Purpose of the Study:
- To provide an updated overview of the functional role of mitochondria in cardiac aging.
Main Methods:
- Comprehensive literature review.
- Analysis of molecular pathways involved in cardiac aging.
- Examination of mitochondrial function in the aging heart.
Main Results:
- Mitochondria play a pivotal role in the aging process of the heart.
- Mitochondrial dysfunction contributes to diminished cardiac function.
- Mitochondria are implicated in various aging-related molecular pathways within the heart.
Conclusions:
- Mitochondria are key players in cardiac aging.
- Understanding mitochondrial roles is essential for addressing age-related heart conditions.
- Further research into mitochondria may reveal therapeutic targets for cardiac aging.
Keywords:
AutophagyRAASROScardiac agingfibrosismitochondriamitophagyneurohormonal systemsoxidative stresssympathetic nervous systemMore Related Videos
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