Benzylic C(sp3)-H fluorination
Alexander P Atkins1, Alice C Dean1, Alastair J J Lennox1
1University of Bristol, School of Chemistry, Bristol, BS8 1TS, U.K.
Abstract:
The selective fluorination of C(sp3)-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp3)-H fluorination, and several methods that are selective for benzylic C-H bonds have been reported. These protocols operate via several distinct mechanistic pathways and involve a variety of fluorine sources with distinct reactivity profiles. This review aims to give context to these transformations and strategies, highlighting the different tactics to achieve fluorination of benzylic C-H bonds.
More Related Videos
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Reactions at the Benzylic Position: Halogenation
Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene
Nucleophilic Aromatic Substitution: Elimination–Addition
Electrophilic Aromatic Substitution: Sulfonation of Benzene
Hybridization of Atomic Orbitals I


