Association between blood inflammatory indicators and prognosis of papillary thyroid carcinoma: a narrative review
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View abstract on PubMed
Summary
This summary is machine-generated.Preoperative inflammation markers like lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) can indicate papillary thyroid cancer (PTC) prognosis. Low LMR and high NLR/platelet-to-lymphocyte ratio (PLR) are linked to poorer outcomes in PTC patients.
Area Of Science
- Oncology
- Immunology
- Medical Diagnostics
Background
- Papillary thyroid carcinoma (PTC) is the most common thyroid cancer, typically indolent but sometimes aggressive.
- Preoperative inflammation indices (LMR, NLR, SII) in blood are explored as nonspecific markers for thyroid cancer.
- Understanding inflammatory markers' role in PTC prognosis is crucial for patient management.
Purpose Of The Study
- To review the association between preoperative inflammatory factors and outcomes in patients with PTC.
- To identify blood indicators that predict prognosis in papillary thyroid cancer.
- To synthesize current evidence on inflammation markers and PTC patient outcomes.
Main Methods
- A narrative review of English articles published from January 2014 to December 2023.
- Searches conducted on PubMed and Web of Science databases.
- Inclusion of studies examining blood indicators and PTC prognosis (TNM staging, survival, recurrence, metastasis).
Main Results
- Low lymphocyte-to-monocyte ratio (LMR) generally correlates with poor PTC prognosis.
- High neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are often associated with adverse outcomes.
- The prognostic value of individual cell counts alone remains unclear.
Conclusions
- Minimally invasive blood indicators offer potential for precise PTC prognosis management.
- Findings on these markers are often conflicting and require validation.
- Prospective, multi-center studies incorporating factors like age are needed to confirm prognostic value.
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