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Updated: Jun 20, 2025

Live Cell Imaging of Alphaherpes Virus Anterograde Transport and Spread
Published on: August 16, 2013
The precise function of alphaherpesvirus tegument proteins and their interactions during the viral life cycle
Yuxi Cui1,2,3,4,5, Mingshu Wang1,2,3,4,5, Anchun Cheng1,2,3,4,5
1Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, China.
Abstract:
Alphaherpesvirus is a widespread pathogen that causes diverse diseases in humans and animals and can severely damage host health. Alphaherpesvirus particles comprise a DNA core, capsid, tegument and envelope; the tegument is located between the nuclear capsid and envelope. According to biochemical and proteomic analyses of alphaherpesvirus particles, the tegument contains at least 24 viral proteins and plays an important role in the alphaherpesvirus life cycle. This article reviews the important role of tegument proteins and their interactions during the viral life cycle to provide a reference and inspiration for understanding alphaherpesvirus infection pathogenesis and identifying new antiviral strategies.
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