Related Experiment Video
Updated: May 5, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
Herpes Simplex Virus Necrotic Lymphadenitis Masquerading as Lymphoma.
Ismail O Malik1, Meenal Malviya1
1Infectious Diseases, Ascension St. John Hospital, Grosse Pointe Woods, USA.
Immunocompromised patients with lymphadenopathy require broad differential diagnoses. A case of chronic lymphocytic leukemia/small lymphocytic lymphoma presented with herpes simplex virus lymphadenitis, not lymphoma progression.
Area of Science:
- Oncology
- Infectious Diseases
- Hematology
Background:
- Lymphadenopathy in immunocompromised patients presents diagnostic challenges.
- Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) can mimic infections or transform into aggressive lymphoma.
- Prompt diagnosis is crucial for appropriate management.
Observation:
- A patient with CLL/SLL presented with fever, dyspnea, and inguinal lymphadenopathy.
- Excisional biopsy revealed herpes simplex virus (HSV) lymphadenitis.
- Immunohistochemical staining confirmed HSV infection.
Findings:
- Flow cytometry excluded progression to diffuse large B-cell lymphoma.
- The lymphadenopathy was attributed to HSV infection rather than CLL/SLL progression or transformation.
- This case underscores the importance of considering infectious etiologies.
Implications:
- Highlights the need for a comprehensive differential diagnosis in immunocompromised patients with lymphadenopathy.
- Emphasizes considering infectious causes, such as HSV lymphadenitis, in patients with CLL/SLL.
- Informs clinical practice regarding the evaluation of lymphadenopathy in immunocompromised individuals on immunosuppressive therapy.
More Related Videos
13:22Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
Published on: January 23, 2014
07:52Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Related Concept Videos
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Cytomegalovirus Disease