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Related Concept Videos

Riboswitches01:56

Riboswitches

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Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
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Thermosensation01:43

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Temperature Measurement Sites01:14

Temperature Measurement Sites

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A thermometer measures body temperature. The common sites for measuring body temperature are the oral cavity, axillary region, temporal artery, and skin surface, such as the forehead, abdomen, and axilla. True core body temperature is assessed in the rectum, tympanic membrane, pulmonary artery, esophagus, and urinary bladder.
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Equipments Used to Measure Body Temperature01:13

Equipments Used to Measure Body Temperature

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Body temperature can be assessed using various devices and measured in Celsius or Fahrenheit.
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Related Experiment Video

Updated: Jun 20, 2025

RIBO-seq in Bacteria: a Sample Collection and Library Preparation Protocol for NGS Sequencing
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Temperature-sensing riboceptors.

Savani Anbalagan1

  • 1Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland.

RNA Biology
|July 17, 2024
PubMed
Summary

Cells need to sense temperature in every organelle. This study proposes riboceptors (ribonucleic acid receptors) that use RNA to detect temperature and initiate thermocrine signaling for various ligands.

Area of Science:

  • Cellular Biology
  • Biophysics
  • Molecular Biology

Background:

  • Temperature sensing is crucial for life's evolution and cellular function.
  • Organisms generate heat through cellular processes, necessitating internal temperature regulation.
  • Existing research identifies protein and nucleic acid-based thermosensors.

Purpose of the Study:

  • To propose the necessity of temperature sensing within every cellular organelle.
  • To introduce the concept of temperature-sensing riboceptors (ribonucleic acid receptors).
  • To establish thermocrine signaling as a mechanism for temperature-triggered cellular events.

Main Methods:

  • Conceptual framework development using an analogy.
  • Literature review of existing thermosensor mechanisms.
Keywords:
RNA thermometerThermocrine signalingThermoreceptorribozymetemperature sensingriboceptor

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  • Hypothetical model proposal for riboceptor function.

    • Main Results:

    • Rationale presented for ubiquitous organelle-specific temperature sensing.
    • Introduction of riboceptors as RNA molecules sensing temperature.
    • Proposal of thermocrine signaling initiated by riboceptors.

    Conclusions:

    • Temperature sensing is essential at the organelle level for cellular function.
    • Riboceptors offer a novel mechanism for cellular temperature detection.
    • This framework may identify sensors for diverse ligands beyond temperature.