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Related Concept Videos

Effects of Chemicals: Overview01:27

Effects of Chemicals: Overview

Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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Related Experiment Video

Updated: Jul 17, 2026

Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens
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The Implementation Moonshot Project for Alternative Chemical Testing (IMPACT) toward a Human Exposome Project.

Fenna C M Sillé1, Francois Busquet2, Suzie Fitzpatrick3

  • 1Center for Alternatives to Animal Testing (CAAT), Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health and Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.

ALTEX
|July 17, 2024
PubMed
Summary

The Human Exposome Project will map lifelong environmental exposures to understand their impact on human health, moving beyond genetics. This initiative uses advanced tech to identify health risks and inform public health policies.

Keywords:
Human Exposome Projectartificial intelligenceenvironmental healthexposomicsmicrophysiological systemstoxicology

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Area of Science:

  • Environmental Health Sciences
  • Toxicology
  • Public Health

Background:

  • The Human Genome Project focused on genetics; the Human Exposome Project expands this to include lifelong environmental exposures.
  • Understanding the complex interplay between environment and health is crucial for disease prevention.

Purpose of the Study:

  • To systematically catalog and analyze individual environmental exposures throughout life.
  • To revolutionize the understanding of how environmental exposures impact human health.
  • To establish exposome intelligence (EI) for integrating and interpreting complex health data.

Main Methods:

  • Leveraging omics technologies, biomonitoring, and microphysiological systems (MPS).
  • Utilizing artificial intelligence (AI) to form the foundation of exposome intelligence (EI).
  • Implementing the Implementation Moonshot Project for Alternative Chemical Testing (IMPACT) through public-private partnerships.

Main Results:

  • Aims to identify exposure-disease links and prioritize hazardous chemicals.
  • Expected to enhance public health and regulatory policies.
  • Will reduce reliance on animal testing in toxicology.

Conclusions:

  • The project promises transformative advancements in precision public health and disease prevention.
  • Fostering interdisciplinary collaboration and robust infrastructure are key to success.
  • Calls for stakeholder support to build a healthier, more sustainable future.