Multicomponent Cross-Dehydrogenative Coupling of Imidazo[1,2-a]pyridine: Access to Abnormal Mannich and Mannich-Type
Segufa Rahaman1, Suhag Singh Sahay1, Annu Kumari1
1Department of Chemistry and Chemical Biology, Indian Institute of Technology (Indian School of Mines), Dhanbad 826004, Jharkhand, India.
Abstract:
This study showcases successfully switchable approaches to accomplish the C3-aryl methylation and C3- amino methylation of privileged nitrogen-containing pharmaceutical compounds "imidazopyridines" with distinct amines, which surmounts the long-standing requirement for a superfluous directing group. These two transformations manifest pronounced regio- and chemo-divergent behavior, successfully demonstrating unprecedented multicomponent "abnormal Mannich and Mannich-type" reactions. The remarkable environmentally benign protocol has been efficiently extended to concise the synthesis and late-stage derivatization.
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