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Related Experiment Video

Updated: Jun 20, 2025

Methods for Detecting Cough and Airway Inflammation in Mice
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Whole Blood Aggregometry in Mice.

Siobhan Branfield1, Yashieta Somani1,2, A Valance Washington1

  • 1Department of Biological Sciences, Oakland University, Rochester Hills, Michigan.

Current Protocols
|July 17, 2024
PubMed
Summary
This summary is machine-generated.

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This study presents a simple protocol for murine whole blood aggregometry, a valuable tool for hematology research. Standardizing this method enhances experimental reliability and aids in understanding platelet function in mice.

Area of Science:

  • Hematology
  • Platelet Physiology
  • Translational Research

Background:

  • Aggregometry is vital for studying platelet function in hematology research and clinical diagnostics.
  • Existing methods like Light Transmission Aggregometry (LTA) and whole blood aggregometry have distinct advantages.
  • While human protocols exist, a standardized murine whole blood aggregometry protocol is lacking.

Purpose of the Study:

  • To introduce a simple, basic protocol for performing whole blood aggregometry in murine models.
  • To provide researchers with an accessible alternative to Light Transmission Aggregometry (LTA) for platelet function analysis in mice.
  • To promote standardization of murine whole blood aggregometry for improved experimental reproducibility.

Main Methods:

  • Development and description of a basic protocol for murine whole blood aggregometry.
Keywords:
aggregometryhematologylight transmission aggregometrylumi‐aggregometrymurine modelsphenylhydrazineplatelet activationplatelet disordersplatelet functionwhole blood aggregometry

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  • Inclusion of a support protocol for inducing phenylhydrazine-induced anemia in wild-type mice.
  • Inclusion of a protocol for determining hematocrit percentage in mice.

    • Main Results:

    • A straightforward protocol for murine whole blood aggregometry is successfully outlined.
    • The protocol offers a physiologically relevant approach to platelet function assessment in mice.
    • The described methods facilitate hematological research in murine models.

    Conclusions:

    • Standardizing whole blood aggregometry protocols in mice is crucial for enhancing experimental reliability.
    • This protocol serves as a valuable resource for hematology researchers studying platelet function.
    • Adoption of this method can facilitate translational research by improving consistency in murine models.