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Updated: Jun 20, 2025

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
Published on: May 16, 2022
CGRP Modulating Therapies: An Update
Kate Bedrin1,2, Tulsi Shah3, Shivani Vaidya3
1Virginia Mason Franciscan Health, Seattle, USA. Kate.Bedrin@commonspirit.org.
Introduction:
Calcitonin-gene related peptide (CGRP) is a vasoactive neuropeptide involved in the pathophysiology ofmigraine. CGRP has been targeted for both preventive and acute treatment of migraine.
Objective:
Provide a summary of the most clinically relevant literature surrounding CGRP modulating therapies.
Methods:
This update on CGRP modulating therapies includes articles selected as most clinically relevant by theauthors.
Conclusion:
CGRP modulating therapies are an exciting new addition to migraine treatment given their safety andtolerability. Additionally, compared to traditional migraine preventive medication these treatments are migrainespecific.Further real-world and clinical data is ongoing to better understand these treatments that continue to gainfavor in the management of migraine.

