Related Experiment Video

Updated: Jun 20, 2025

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
12:44

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Published on: November 11, 2014

12.3K

Transcription Factor NRF2 in Shaping Myeloid Cell Differentiation and Function

Marc Pfefferlé1, Florence Vallelian2

  • 1Department of Internal Medicine, Spital Limmattal, Schlieren, Switzerland.

Advances in Experimental Medicine and Biology
|July 17, 2024
PubMed

Insights

Nuclear factor erythroid 2-related factor 2 (NRF2) regulates myeloid cell functions and impacts numerous diseases. Activating NRF2 can reduce inflammation and offers therapeutic potential for myeloid cell-driven pathologies.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Nuclear factor erythroid 2-related factor 2 (NRF2) is a master transcription factor.
  • NRF2 regulates cellular homeostasis, including antioxidant responses, autophagy, proteostasis, and metabolism.
  • Emerging evidence highlights NRF2's critical role in modulating inflammatory and immune processes.

Purpose of the Study:

  • To explore the function of NRF2 in myeloid cell differentiation and function.
  • To investigate the implications of NRF2 in myeloid cell-driven diseases.
  • To discuss the therapeutic potential of NRF2 modulation.

Main Methods:

  • Literature review and synthesis of existing research on NRF2.
  • Analysis of NRF2's role in macrophages, dendritic cells, and neutrophils.
  • Examination of NRF2's involvement in various disease contexts.

Main Results:

  • NRF2 modulates key functions in macrophages (cytokine production, phagocytosis, metabolism).
  • NRF2 influences dendritic cell maturation, cytokine production, and antigen presentation.
  • NRF2 is involved in neutrophil activation, migration, cytokine production, and NETosis.
  • NRF2 activation generally reduces inflammation, impacting disease outcomes.

Conclusions:

  • NRF2 plays a significant role in myeloid cell biology and function.
  • Dysregulation of NRF2 is implicated in a wide range of diseases.
  • Modulating NRF2 presents a promising therapeutic strategy for myeloid cell-driven diseases.
Keywords:
Dendritic cellsInflammationInnate immunityMacrophagesMyeloid cellsMyeloid differentiationNFE2-related factor 2 (NRF2)Neutrophils

More Related Videos

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

9.9K
Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro06:12

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

3.4K

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
75.8K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.4K
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.2K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
146.9K