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Circulating Activated Platelets in Children With Long COVID: A Case-Controlled Preliminary Observation
Danilo Buonsenso1,2, Silvia Sorrentino3, Antonietta Ferretti3
1From the Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Children with Long COVID show increased platelet activation. This study found higher levels of platelet activation markers in children experiencing Long COVID compared to healthy children, suggesting a potential role for platelets in the condition.
Area of Science:
- Hematology
- Immunology
- Pediatrics
Background:
- Long COVID, a condition affecting children post-infection, presents with diverse symptoms.
- Platelets play a crucial role in hemostasis and immune responses.
- Evidence suggests platelet activation may contribute to Long COVID pathophysiology.
Purpose of the Study:
- To investigate platelet activation in children with Long COVID.
- To compare platelet activation markers between children with Long COVID and healthy controls.
Main Methods:
- Flow cytometry was used to analyze platelet activation markers.
- Monoclonal antibodies against P-selectin, CD63, and PAC-1 were employed.
- Platelets were analyzed in both quiescent and stimulated states.
Main Results:
- Children with Long COVID exhibited significantly increased expression of the platelet activation marker P-selectin.
- This finding was statistically significant (P = 0.019).
Conclusions:
- Circulating platelets in children with Long COVID demonstrate heightened activation.
- Increased platelet activation may be a contributing factor to the development or persistence of Long COVID symptoms in pediatric populations.
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