Related Experiment Video
Updated: Jun 20, 2025

Taste Exam: A Brief and Validated Test
Published on: August 17, 2018
Sweet-bitter taste interactions in binary mixtures of sweeteners: Relationship between taste receptor activities and
Yoonha Choi1, Run Rou Wong1, Yeon Kyung Cha2
1Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Republic of Korea.
Abstract:
This study investigated the effects of various binary sweetener mixtures on sweetness enhancement and their interactions with sweet or bitter taste receptors, focusing on sensory perception and receptor activity. Acesulfame K or saccharin was mixed with allulose, aspartame, erythritol, fructose, glucose, or sucrose to match a target sucrose sweetness. The effects of the mixtures on sweet and bitter taste receptors (in the human embryonic kidney -293 cells) and sensory taste intensities were evaluated. Sweetness enhancement at the sweet taste receptor level was observed in some cases, with several monosaccharides reducing the acesulfame K- or saccharin-induced bitter taste receptor activity. Combining acesulfame K or saccharin with any of the six sweeteners perceptually enhanced sweetness (60% ∼ 100% in 50:50 ratio), correlating with a reduction in inherent bitterness (-35% ∼ -63% in 50:50 ratio). This finding suggests that sweetness perception likely increased because the monosaccharides mitigate the activation of bitter receptors caused by high-potency sweeteners.
More Related Videos
09:17Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults
Published on: July 16, 2016
08:52Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test
Published on: April 21, 2021
Related Concept Videos
The Physiology of Taste
Gustation
Taste Buds and Receptors
Tactile and Chemical Senses
G-Protein Gated Ion Channels
Sensory...
The Two-State Receptor Model
The binding affinity of a drug determines its interaction with...