21-Gene Recurrence Score and Survival Outcomes in the Phase III Multicenter TAILORx Clinical Trial
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View abstract on PubMed
Summary
This summary is machine-generated.The 21-gene recurrence score (RS) independently predicts breast cancer-specific survival and recurrence, offering more prognostic value for these outcomes than overall survival in early-stage disease.
Area Of Science
- Oncology
- Genomic Medicine
- Clinical Trial Analysis
Background
- The 21-gene recurrence score (RS) is widely used to guide adjuvant chemotherapy decisions in early-stage breast cancer.
- Its independent prognostic value for breast cancer-specific survival (BCSS) and overall survival (OS) in the TAILORx trial population requires further clarification.
Purpose Of The Study
- To evaluate the association of RS with BCSS, OS, recurrence-free interval (RFI), and invasive disease-free survival (DFS).
- To determine if RS provides independent prognostic information beyond clinicopathologic factors for these outcomes.
Main Methods
- Multivariable Cox proportional hazards regression analysis was performed on 8,916 patients with hormone receptor-positive, HER2-negative, node-negative breast cancer.
- Likelihood ratio (LR) tests assessed the relative prognostic information of RS for BCSS, OS, RFI, and DFS.
Main Results
- Higher RS (midrange and high-range) was associated with inferior BCSS and RFI, independent of clinicopathologic factors.
- High-range RS was linked to increased DFS risk, but not significantly to OS.
- Midrange RS showed no significant association with DFS or OS.
Conclusions
- The recurrence score (RS) is an independent prognostic factor for BCSS and recurrence in early-stage breast cancer.
- RS provides greater prognostic information for breast cancer-specific outcomes compared to overall survival.
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