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Updated: Jun 20, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Target Volume Optimization for Localized Prostate Cancer.

Krishnan R Patel¹, Uulke A van der Heide², Linda G W Kerkmeijer³

¹Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Practical Radiation Oncology

|July 17, 2024

Summary

This summary is machine-generated.

Optimizing radiation therapy for prostate cancer involves precise target volume definition, especially for focal boost techniques. Advanced imaging aids dose escalation, but knowledge gaps remain for optimal treatment planning.

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Area of Science:

Radiation Oncology
Medical Imaging
Prostate Cancer Research

Background:

Traditional prostate cancer treatment involved uniform radiation doses to the entire prostate.
Advances in prostate-specific imaging, including MRI and PET, enable precise localization of high-risk tumor subvolumes.

Purpose of the Study:

To review methods for optimizing target volume definition in prostate cancer radiation therapy.
To emphasize the specific challenges and strategies for focal boost volume definition.

Main Methods:

A narrative review of existing literature on target volume definition for localized prostate cancer treatment.
Synthesis of current knowledge regarding imaging and pathological correlates for treatment planning.

Main Results:

Focal dose escalation to high-risk prostate subvolumes improves biochemical control with acceptable toxicity.
Advanced imaging (MRI, PET) allows for precise identification and targeting of these high-risk areas.
Uncertainty persists regarding optimal target volume definition and prescription strategies for focal boost techniques.

Conclusions:

Advanced imaging is crucial for improving prostate cancer patient outcomes through focal dose escalation.
Significant knowledge gaps remain concerning the optimal definition and prescription strategies for focal boost radiation therapy.
Understanding pathological correlates and tumor spread patterns is essential for informed clinical judgment in target volume definition.