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Published on: June 28, 2018
Biomarker of severity in hospitalised patients with COVID-19: a retrospective study
Fen-Hong Qian1, Yu-Xue Liu2, Yu Cao2
1Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China zhaoqian604@126.com.
Insights
The novel coronavirus (COVID-19) caused millions of deaths globally. This study found that the albumin-neutrophil count to lymphocyte count ratio score (ANS) can predict COVID-19 severity.
Area of Science:
- Medical Research
- Infectious Diseases
- Biomarkers
Background:
- The COVID-19 pandemic caused significant global mortality.
- Severe cases of COVID-19 had high mortality rates.
Purpose of the Study:
- To evaluate the albumin-neutrophil count to lymphocyte count ratio score (ANS) as a prognostic indicator for COVID-19 severity.
- To determine if ANS can predict the likelihood of severe disease progression.
Main Methods:
- Retrospective study design.
- Patients classified as non-severe (n=270) or severe (n=100) based on WHO criteria.
- Analysis of neutrophil count to lymphocyte count ratio (NLR), serum albumin levels, and ANS.
Main Results:
- Severe COVID-19 patients exhibited significantly higher NLR and lower serum albumin levels.
- Optimal cut-off values for serum albumin and NLR were identified as 33.5 g/L and 8.25, respectively.
- Serum albumin, NLR, and ANS were independent prognostic indicators of severe COVID-19.
Conclusions:
- The albumin-neutrophil count to lymphocyte count ratio score (ANS) can serve as a prognostic indicator for COVID-19 severity.
- ANS provides valuable information for predicting disease progression in COVID-19 patients.
Background:
The novel COVID-19 was rapidly spreading and was highly contagious. COVID-19 caused over 6 million deaths worldwide, with high mortality rates, particularly in severe cases.
Objective:
This study aimed to investigate whether serum albumin-neutrophil count to lymphocyte count ratio (NLR) score (ANS) could be used as a prognostic indicator of COVID-19 severity.
Design:
A retrospective study.
Participants:
Based on the WHO diagnostic criteria, patients were classified as either non-severe (n=270) or severe (n=100).
Primary And Secondary Outcome Measures:
NLR, serum albumin level and ANS.
Main Results:
The NLR of patients with severe disease was significantly higher than that of those with non-severe disease. Serum albumin levels were significantly lower in patients with severe disease than in those with non-severe disease. The cut-off values representing the maximum potential effectiveness of serum albumin and NLR were 33.5 g/L and 8.25, respectively, according to the Youden index. In patients with severe COVID-19, we observed that the serum albumin level, NLR and ANS were independent prognostic indicators of severe COVID-19 using logistic analysis. The relative risk of severe COVID-19 was 7.65 (95% CI 3.72 to 15.75, p<0.05) in the ANS 2 group compared with that in ANS 0.
Conclusions:
ANS could be used as a prognostic indicator of COVID-19 severity.
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