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Updated: Jun 20, 2025

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
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The emerging role of fibrin(ogen) in cardiovascular disease

Hong Lan1, Shengtao Zhao1, Yuting Xiong1

  • 1Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Periodontology, Stomatological Hospital and Dental School, Tongji University, Yanchang Road 399, Shanghai, 200072, P. R. China.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|July 17, 2024
PubMed

Insights

Fibrinogen, a key protein in blood clotting, significantly impacts cardiovascular disease development. Understanding its role in thrombosis and inflammation is crucial for new therapeutic strategies.

Area of Science:

  • Biochemistry
  • Cardiology
  • Molecular Biology

Background:

  • Fibrinogen is a liver-produced coagulation factor essential for hemostasis.
  • Emerging research highlights fibrinogen's critical role in cardiovascular disease (CVD) regulation.
  • Understanding fibrinogen's mechanisms in CVD is vital for public health.

Purpose of the Study:

  • To review the specific involvement of fibrinogen in cardiovascular disease.
  • To elucidate the underlying molecular mechanisms of fibrinogen's role in CVD pathogenesis.

Main Methods:

  • A comprehensive literature review was performed.
  • PubMed database was utilized to identify relevant studies.
  • Emerging roles of fibrinogen in CVD were analyzed.

Main Results:

  • Fibrinogen plays a pivotal role in cardiovascular disease pathogenesis.
  • Fibrinogen influences thrombosis formation and inflammatory responses.
  • Multiple molecular pathways are modulated by fibrinogen in CVD.

Conclusions:

  • Fibrinogen is integral to the pathogenesis and progression of cardiovascular diseases.
  • Fibrinogen's functions in CVD mechanisms are multifaceted.
  • Fibrinogen presents a promising target for novel cardiovascular therapies.
Abstract

Keywords:
Cardiovascular diseaseCoagulationFibrinFibrinogen

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