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A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
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Phase separation provides a mechanism to drive phenotype switching

Lijun Hong1, Zhenquan Zhang1, Zihao Wang1

  • 1Guangdong Province Key Laboratory of Computational Science, <a href="https://ror.org/0064kty71">Sun Yat-sen University</a>, Guangzhou 510275, People's Republic of China and School of Mathematics, <a href="https://ror.org/0064kty71">Sun Yat-Sen University</a>, Guangzhou 510275, People's Republic of China.

Physical Review. E
|July 18, 2024
PubMed
Summary

Protein compartmentalization via liquid-liquid phase separation influences cell fate. Our model shows phase separation drives bistability and controls cell fate decisions, particularly within the droplet phase.

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