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Photo-Clickable Triazine-Trione Thermosets as Promising 3D Scaffolds for Tissue Engineering Applications.

Åshild Johansen1, Jinjian Lin2, Shuntaro Yamada1

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|July 18, 2024
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Summary
This summary is machine-generated.

A new heterocyclic triazine-trione (TATO) material platform enables room-temperature fabrication of versatile tissue engineering scaffolds. These cytocompatible TATO materials support cell growth and differentiation, showing promise for regenerative medicine applications.

Keywords:
biocompatibilityregenerative medicinethermosetthiol‐enethiol‐ynetissue engineeringtriester‐triazine‐trione

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Tissue Engineering

Background:

  • High glass transition temperatures of conventional polymeric scaffolds limit their use in tissue engineering.
  • There is a significant need for advanced scaffolding materials with tunable properties for regenerative medicine.

Purpose of the Study:

  • To develop a novel, solvent-free materials platform for fabricating tissue engineering scaffolds.
  • To investigate the properties and biological performance of heterocyclic triazine-trione (TATO) based thermosets.

Main Methods:

  • Fabrication of tissue engineering scaffolds using solvent-free, two-component TATO formulations cured via thiol-ene/yne photochemistry.
  • Characterization of scaffold properties including mechanical modulus, glass transition temperature (Tg), and surface morphology.
  • In vitro assessment of cytocompatibility, cell proliferation, apoptosis, and differentiation of mesenchymal stem cells.

Main Results:

  • Three TATO thermosets (TATO-1, TATO-2, TATO-3) were synthesized and fabricated into various scaffold forms (discs, films, sponges, 3D printed objects).
  • Scaffolds exhibited a wide range of mechanical properties, with Tg values from 30.4°C to 62.5°C.
  • Materials demonstrated suitable micro/nano-surface morphologies for bone tissue engineering, were cytocompatible, supported cell proliferation, and facilitated differentiation into osteoblasts, adipocytes, and neuronal cells.

Conclusions:

  • TATO materials offer a versatile and tunable platform for tissue engineering scaffold fabrication.
  • The solvent-free, room-temperature curing process is advantageous for creating complex scaffold architectures.
  • These novel biomaterials show significant potential for diverse clinical applications in regenerative medicine.