Related Experiment Video
Updated: Jun 20, 2025
08:20
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
13.9K
Online mindfulness-based cognitive therapy for treatment-resistant depression: a parallel-arm randomized controlled
Michele Ferreira Rodrigues1, Laiana Quagliato1, Jose Carlos Appolinario1
1Institute of Psychiatry (IPUB) of Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Frontiers in Psychology
|July 18, 2024
Summary
Online mindfulness-based cognitive therapy (eMBCT) effectively reduced depression and anxiety symptoms in individuals with treatment-resistant depression (TRD). This digital mental health intervention shows promise for improving clinical outcomes in TRD patients.
Area of Science:
- Mental Health
- Clinical Psychology
- Digital Therapeutics
Background:
- Treatment-resistant depression (TRD) affects a significant portion of major depressive disorder patients, leading to poor treatment outcomes.
- Digital mental health innovations, such as online mindfulness-based cognitive therapy (eMBCT), offer accessible solutions for TRD management.
- eMBCT presents a promising avenue for enhancing mental health care delivery in clinical settings for TRD.
Purpose of the Study:
- To evaluate the feasibility of an individual online mindfulness-based cognitive therapy (eMBCT) program for reducing depressive symptoms in patients with TRD.
- To assess the efficacy of eMBCT in an individual clinical context for TRD patients.
Main Methods:
- A randomized controlled feasibility trial was conducted with 28 outpatients diagnosed with TRD.
- Participants were assigned to either an 8-week eMBCT program delivered via live video sessions or a control group.
- Standardized questionnaires were used for assessments at baseline and study completion.
Main Results:
- The eMBCT group demonstrated significant reductions in depression symptoms (p=0.001) and anxiety symptoms (p=0.001).
- Compared to the control group, the eMBCT group showed significant reductions in depression symptoms (p=0.015) and improved clinical global impressions (p=0.004).
- No significant changes were observed in the control group during the initial assessment period.
Conclusions:
- Individual eMBCT, when combined with medication, appears to be a feasible and effective treatment for reducing depressive symptoms in TRD.
- Future trials could explore incorporating a manualized intervention for the control group to further refine treatment comparisons.
Related Concept Videos
01:25Cognitive Therapy
149
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
149
01:24Rational Emotive Behavior Therapy
48
Cognitive-behavioral therapies (CBTs) are grounded in the belief that our thoughts profoundly influence our emotions and actions. Advocates of CBT emphasize three core assumptions: first, that cognitions are identifiable and measurable; second, that they are central to psychological functioning; and third, that irrational or maladaptive beliefs can be replaced with rational and adaptive ones. This transformative approach to therapy has paved the way for specific models such as Albert...
48