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Related Experiment Video

Updated: Jun 20, 2025

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
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Choroidal Thickness in Mild Autonomous Cortisol Secretion.

Sezin Dogan Cakir1, Akin Cakir2, Feyza Yener Ozturk3

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Health Sciences Türkiye, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Türkiye.

Sisli Etfal Hastanesi Tip Bulteni
|July 18, 2024
PubMed
Summary

Patients with mild autonomous cortisol secretion (MACS) show increased choroidal thickness (CT). This thicker choroid may serve as a diagnostic biomarker for hypercortisolemia and related comorbidities in MACS patients.

Keywords:
Choroidal thicknessmild autonomous cortisol secretionoptical coherence tomographypossible autonomous cortisol secretion

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Area of Science:

  • Ophthalmology
  • Endocrinology
  • Medical Diagnostics

Background:

  • Mild autonomous cortisol secretion (MACS) is a condition with potential health implications.
  • Assessing diagnostic tools for MACS is crucial for patient management.

Purpose of the Study:

  • To evaluate choroidal thickness (CT) in patients with MACS.
  • To determine if CT can be a diagnostic tool for MACS.

Main Methods:

  • A cross-sectional study comparing 27 MACS patients with 25 healthy controls.
  • Choroidal thickness (CT) was measured using Spectralis optical coherence tomography.

Main Results:

  • MACS patients exhibited significantly thicker choroids than controls across all measurement areas (p<0.001).
  • Choroidal thickness correlated with 2 mg dexamethasone suppression test results.
  • Pachychoroid pigment epitheliopathy was more frequent in the MACS group.

Conclusions:

  • Increased choroidal thickness is observed in MACS patients.
  • Thicker choroids in MACS patients may indicate a novel diagnostic biomarker for hypercortisolemia and associated comorbidities.