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  11. Sevelamer-induced Ischemic Enteritis.
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  5. Chemical Sciences
  7. Inorganic Chemistry
  9. Inorganic Chemistry Not Elsewhere Classified
  11. Sevelamer-induced Ischemic Enteritis.

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Sevelamer-Induced Ischemic Enteritis.

Hannah Darnell1, Aaron Brenner2, Cody Kern2

  • 1Department of Internal Medicine, University of Kentucky, Lexington, KY.

ACG Case Reports Journal
|July 18, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Sevelamer, a phosphate binder, can rarely cause gastrointestinal injury. This case highlights a patient with end-stage renal disease who developed sevelamer-induced ischemic enteritis.

Keywords:
ischemic enteritissevelamersevelamer crystals

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Area of Science:

  • Nephrology
  • Gastroenterology
  • Pathology

Background:

  • Hyperphosphatemia is a common complication in patients with renal impairment, increasing mortality risk.
  • Sevelamer is a widely used phosphate binder to manage hyperphosphatemia.
  • Gastrointestinal mucosal injury is a rare but documented adverse effect of sevelamer therapy.

Observation:

  • A 35-year-old male patient with end-stage renal disease on peritoneal dialysis presented with abdominal pain and hematochezia.
  • Initial diagnostic workup, including imaging and endoscopy, suggested ischemic enteritis.
  • Histopathological examination revealed crystalloid structures with surrounding necrosis.

Findings:

  • The crystalloid structures were identified as sevelamer crystals.
  • The findings were consistent with sevelamer-induced ischemic enteritis.
  • This case underscores a rare gastrointestinal complication of sevelamer treatment.

    • Implications:

    • Clinicians should consider sevelamer crystal deposition as a potential cause of gastrointestinal injury in patients with renal impairment.
    • Prompt recognition and diagnosis are crucial for managing sevelamer-induced enteritis.
    • Further research may be warranted to elucidate the exact mechanisms and risk factors for this rare complication.