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Related Experiment Videos

Timolol: long-term Canadian multicentre study.

R P LeBlanc, N E Saheb, G Krip

    Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
    |June 1, 1985
    PubMed
    Summary
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    Timolol maleate ophthalmic preparations effectively treated glaucoma over 200 weeks in Canadian patients. The drug lowered intraocular pressure with minimal side effects, showing good tolerability.

    Area of Science:

    • Ophthalmology
    • Pharmacology

    Background:

    • Glaucoma is a leading cause of irreversible blindness worldwide.
    • Effective intraocular pressure (IOP) management is crucial for glaucoma treatment.
    • Timolol maleate is a commonly prescribed beta-blocker for IOP reduction.

    Purpose of the Study:

    • To evaluate the long-term efficacy and safety of timolol maleate ophthalmic preparations.
    • To assess the sustained IOP-lowering effect of timolol maleate over 200 weeks.

    Main Methods:

    • A 200-week, multi-center study involving 117 glaucoma patients across Canada.
    • Patients were treated with timolol maleate ophthalmic preparations under a strict protocol.
    • Intraocular pressure, pulse rate, and perfusion pressure were monitored.

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    Main Results:

    • Timolol maleate effectively maintained IOP below 22 mm Hg in 60% of treated eyes (137/227) throughout the study.
    • No clinically significant effects on pulse rate or mean perfusion pressure were observed.
    • The ophthalmic preparation demonstrated good tolerability with few adverse reactions.

    Conclusions:

    • Timolol maleate ophthalmic preparations are an effective and well-tolerated long-term treatment for glaucoma.
    • Sustained IOP control can be achieved with timolol maleate, reducing the risk of vision loss.
    • The safety profile supports its continued use in glaucoma management.