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Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

A practical focus on fish and shellfish oral immunotherapy.

Douglas P Mack¹, Margaret Woch², Pablo Rodríguez Del Río³

¹From the McMaster University, Hamilton, Ontario, Canada.

Journal of Food Allergy

|July 18, 2024

Summary

This summary is machine-generated.

Oral immunotherapy (OIT) for fish and shellfish allergies is uncommon due to practical and immunological challenges. Further standardization is needed, but experienced physicians may consider OIT for motivated patients.

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Area of Science:

Allergy and Immunology
Food Science

Background:

Fish and shellfish allergies are prevalent globally, often leading to severe reactions like anaphylaxis.
Despite the high prevalence, oral immunotherapy (OIT) for these allergies is rarely implemented.

Purpose of the Study:

To review the existing literature on oral immunotherapy (OIT) for fish and shellfish allergies.
To identify the challenges and considerations associated with seafood OIT.

Main Methods:

A comprehensive review of limited scientific literature pertaining to seafood OIT.
Analysis of practical and immunological hurdles encountered in seafood OIT protocols.

Main Results:

Significant practical challenges include undesirable taste and odor, and inconsistent cross-reactivity.
Immunological challenges involve alterations in protein concentration due to cooking and other factors.
The literature on seafood OIT is limited, highlighting a need for standardization.

Conclusions:

Seafood OIT presents unique difficulties that limit its common application.
Ongoing efforts to standardize seafood OIT protocols are essential.
Experienced allergists may consider OIT for highly motivated individuals with seafood allergies.