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Progress in SARS-CoV-2, diagnostic and clinical treatment of COVID-19

Yang Li1,2, Si-Ming Lu3,4,5, Jia-Long Wang1,2

  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Heliyon
|July 18, 2024
PubMed
Abstract

Insights

This review summarizes Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) structure and infection, highlighting the need for effective COVID-19 treatments. It examines viral proteins and targeted antiviral drugs for future therapeutic development.

Area of Science:

  • Virology
  • Infectious Diseases
  • Drug Discovery

Background:

  • COVID-19, caused by SARS-CoV-2, is a global pandemic.
  • Rapid testing is crucial for patient management and disease control.
  • Effective antiviral treatments for SARS-CoV-2 remain limited.

Purpose of the Study:

  • To review current knowledge on SARS-CoV-2 structure, infection, and detection.
  • To explore potential therapeutic targets, including viral proteases and RNA polymerase.
  • To discuss ongoing research in pathogenesis, diagnosis, and vaccine development.

Main Methods:

  • Literature review of viral structure and function.
  • Analysis of SARS-CoV-2 specific proteins (protease, RNA polymerase).
  • Examination of existing and potential antiviral drug strategies.

Main Results:

  • Detailed insights into the structure of key SARS-CoV-2 proteins.
  • Identification of specific viral components as potential drug targets.
  • Overview of various antiviral approaches and their progress.

Conclusions:

  • Understanding viral structure is key to developing targeted therapies.
  • Further research into pathogenesis and clinical trials is essential.
  • Development of effective COVID-19 treatments is ongoing.
Keywords:
COVID-19DiagnosisPharmacological treatmentSARS-CoV-2

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