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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Allergic Reactions02:06

Allergic Reactions

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Overview
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Related Experiment Video

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Basophil Activation Test for Allergy Diagnosis
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Food allergy and asthma.

Angela Chan1, Joyce E Yu1

  • 1From the Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York.

Journal of Food Allergy
|July 18, 2024
PubMed
Summary

Children with food allergies (FA) have a higher risk of developing asthma. Managing both conditions is crucial for better health outcomes and preventing severe reactions like anaphylaxis.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Clinical Immunology

Background:

  • Food allergies (FA) affect up to 8% of US children, while asthma impacts 14%.
  • Children with FA are 2-4 times more likely to have asthma compared to those without FA.
  • Early food sensitization is a predictor of childhood asthma onset, with multiple FAs increasing risk.

Purpose of the Study:

  • To examine the intricate relationship between food allergies and asthma.
  • To highlight the impact of coexisting FA and asthma on patient outcomes.
  • To emphasize optimal management strategies for patients with both conditions.

Main Methods:

  • Review of existing epidemiological data and clinical studies.
  • Analysis of the association between food sensitization, FA, and asthma development.

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  • Evaluation of the impact of coexisting conditions on asthma control and healthcare utilization.

    • Main Results:

    • Food sensitization and FA are significant predictors of childhood asthma.
    • Coexisting FA and asthma lead to poor asthma control, increased healthcare use, and higher risk of fatal anaphylaxis.
    • Asthma is a risk factor in approximately 75% of fatal food-related anaphylaxis cases.

    Conclusions:

    • Integrated management of FA and asthma is essential, including patient education and optimized asthma therapy.
    • Allergists must ensure asthma control before oral food challenges.
    • Biologic therapies like omalizumab and dupilumab are being investigated for FA treatment.