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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivities01:30

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Related Experiment Video

Updated: Jun 20, 2025

Basophil Activation Test for Allergy Diagnosis
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Biologic therapy for food allergy.

Meng Chen1,2, Wenming Zhang1, Lisa Lee1

  • 1From the Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, California, and.

Journal of Food Allergy
|July 18, 2024
PubMed
Summary

Biologics show promise for improving food allergy treatments by enhancing oral immunotherapy (OIT) safety and reducing duration. Research explores biologics and vaccines as standalone or combined therapies for better food allergy management.

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Area of Science:

  • Immunology
  • Allergy and Immunology
  • Pharmacology

Background:

  • Food allergies affect 6-13% globally, posing a significant health challenge.
  • Oral immunotherapy (OIT) shows promise but has limitations like adverse reactions and long treatment times.

Purpose of the Study:

  • To explore the potential of biologics in improving the safety and efficacy of food allergy treatments.
  • To review current investigations into biologics and vaccines for food allergy management.

Main Methods:

  • Review of biologics targeting key molecules in food allergy, including anti-IgE, anti-IL-4Rα, anti-IL-5, anti-IL-5R, and anti-IL-33 therapies.
  • Investigation of peanut DNA plasmid vaccines.
  • Exploration of biologics as monotherapy and adjunctive therapy with OIT.

Main Results:

  • Several biologics are under investigation for food allergy treatment.
  • Biologics aim to increase OIT safety and reduce treatment duration.
  • Vaccines and biologics are being explored for both monotherapy and combination therapy.

Conclusions:

  • Biologics offer a promising future for food allergy treatment, potentially enhancing OIT and providing insights into disease mechanisms.
  • Precision medicine approaches, including biologics, are advancing food allergy care.
  • Further research into biologics and vaccines is crucial for developing safer and more effective food allergy therapies.