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Oxidative Stress in Prediabetic Young Adults
Irfan G Mulla1, Ashish Anjankar1, Shilpa A Pratinidhi2
1Biochemistry, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus
|July 18, 2024
Summary
Prediabetic young adults exhibit elevated oxidative stress markers like malondialdehyde (MDA) and nitric oxide (NO), increasing their risk for developing type 2 diabetes mellitus (T2DM). Early intervention is crucial to prevent complications.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Oxidative Stress Research
Background:
- Oxidative stress, indicated by malondialdehyde (MDA) and nitric oxide (NO), is implicated in diabetes complications.
- Prediabetes is associated with increased risk of type 2 diabetes mellitus (T2DM) and its complications.
- Early cell injury in diabetes may stem from acute blood glucose elevations.
Purpose of the Study:
- To investigate whether oxidative stress parameters are altered in prediabetic young adults.
- To determine if oxidative stress in prediabetics elevates the risk of developing T2DM.
Main Methods:
- Study involved prediabetic and non-prediabetic young adults (18-35 years) from a tertiary hospital in India.
- Measured oxidative stress biomarkers: malondialdehyde (MDA) and nitric oxide (NO).
- Assessed anthropometric parameters: body weight, waist circumference, and body mass index (BMI).
Main Results:
- Prediabetic individuals showed significantly higher levels of MDA (P < 0.001) and NO (P < 0.001) compared to controls.
- Prediabetics also had significantly greater body weight, waist circumference, and BMI.
- These findings indicate deranged oxidative stress parameters in prediabetics.
Conclusions:
- Early identification and management of hyperglycemia in prediabetics are vital.
- Impaired pancreatic beta-cell function and insulin resistance precede T2DM onset.
- Targeting inflammation and oxidative stress may prevent T2DM progression and associated cardiovascular diseases (CVDs).
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