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Atypical Presentation of a Patient With Progressive Multifocal Leukoencephalopathy
Saimounika Adapa1, Nilesh Jagdale1, Kalyan K Vutukuru1
1Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.
Cureus
|July 18, 2024
Summary
Progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the John Cunningham (JC) virus, can occur in immunocompromised individuals. Early diagnosis via PCR in cerebrospinal fluid is crucial for managing this demyelinating disease.
Area of Science:
- Neuroscience
- Infectious Diseases
- Virology
Background:
- Progressive multifocal leukoencephalopathy (PML) is a rare, demyelinating central nervous system disease.
- It primarily affects immunosuppressed individuals, often linked to human immunodeficiency virus (HIV) or immunosuppressive therapies.
- The John Cunningham (JC) polyomavirus is the causative agent, reactivating in immunocompromised hosts.
Keywords:
antiretroviral therapydemyelinationhiv aidsimmunocompromisedjohn cunningham (jc) viruspmlprogressive multifocal leukoencephalopathy (pml)More Related Videos
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